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hematology anemia mds myelodysplastic apml approach chronic cll differentiation diffuse erythematosus gap globulin hodgkins lad lupus lymphadenopathy lymphocytic lymphoma myelodysplasia
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... (CBC with Lymphocytes ... #Diagnosis #Algorithm ... #Causes #Hematology ... #Oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Artifact (redo CBC ... Infectious: • Acute ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Diagnosis Algorithm ... Megakaryopoiesis • Aplastic ... Leukemia, Tumour ... #Diagnosis #Algorithm ... #Causes #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... transformation to acute ... leukemia Management ... #hematology #oncology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm ... Blood Loss • Acute ... Deficiency • Aplastic ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Diagnosis Algorithm ... • Marrow Aplasia ... Normal RBCs • Acute ... #Diagnosis #Algorithm ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... virus (EBV) • Leukemia ... #Anemia #oncology ... #hematology #diagnosis ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... Pure red cell aplasia ... ’s lymphoma or acute ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... Neutrophils • Immature/Myeloblasts ... • Tumor lysis syndrome ... #Hematology #Oncology ... #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... initiation • Differential ... Differentiation #Syndrome ... #management #hematology ... #oncology
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