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differential algorithm management secondary chronic cll fingernail generalized lines lymphocytic monoclonal myelodysplastic nail nails pathology platelets pruritus rheumatology activation aplastic
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... #Causes #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential Diagnosis ... Chronic Myelogenous Leukemia ... Iron deficiency anemia ... #Hematology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - ... Reactive: • Anemia ... Chronic Myeloid Leukemia ... #causes #Platelets ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
(MD) - Diagnosis ... cytopenias (usually anemia ... #MDS #Diagnosis ... Management #treatment #hematology ... #oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Reactive: - Systemic ... #Algorithm #Causes ... #Hematology #Oncology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential Diagnosis ... • Lymphoma • Leukemia ... vera, essential thrombocytosis ... Inflammatory • Systemic ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Kawasaki, Nephrotic syndrome ... Matthew Ho, MD ... #Algorithm #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Cancer: • Leukemia ... Autoimmune Diseases: • Systemic ... #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
and Primary Causes ... renal failure/uremia ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #generalized #dermatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... #Hematology
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