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causes thrombocytosis workup atlas classification disease disorders elevatedmcv leukemia macrocytic macrocytosis management mds microcytic monoclonal morphology myelodysplastic platelets rbc agglutinin
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Diagnosis Platelet ... Reactive: • Anemia ... /blood loss (Fe ... Myelofibrosis • Chronic Myeloid ... #Platelets #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... : Acute blood loss ... #Diagnosis #Algorithm ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... Thrombocytosis): • Acute ... malignancies • Anemia ... MF) • Chronic myeloid ... #hematology #secondary
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Diagnosis Algorithm ... Acute • Myloid ... Pelger-Huet, Macrocytic anemia ... #Disorders #hematology ... #Diagnosis #Algorithm
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Infectious: • Acute ... Iron deficiency anemia ... #Diagnosis #Algorithm ... #Causes #Hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Diagnosis Framework ... the total white blood ... Disorders: • Chronic myeloid ... myeloid leukemia ... #hematology #basophils
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm ... Blood Loss ... • Acute Bleed - ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Diagnosis Algorithm ... Normal Blood Smear ... Formation • Multiple Myeloma ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Diagnosis Algorithm ... Normal RBCs • Acute ... Diagnosis #Algorithm ... #Causes #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Management Summary myelo ... cytopenias (usually anemia ... transformation to acute ... Management #treatment #hematology ... #oncology
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