18 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
level of muscle weakness ... anti-synthetase syndrome ... Can also see mechanics ... have significant weakness ... Myositis #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Erythematosus (SLE ... 80%) - Proximal Weakness ... femoral heads • Myopathy ... Erythematosus #SLE ... Complications #pathophysiology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... Aseptic Meningitis, Myelopathy ... Disease, PRES Pathophysiology ... CNS #neurology #rheumatology
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... erythematosus (SLE ... antisynthetase syndrome
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
TIF1y, NXP2, Mi-2, SAE ... Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... clinical #diagnosis #rheumatology
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
/paralysis - Weakness ... - Radiation myelopathy ... - Radiation myelopathy ... Behcet disease - SLE ... MCTD, Sjogren syndrome
Causes of Pericardial Effusion - Differential Diagnosis
Infectious:
 • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus
 • Bacterial: Mycobacterium
Non-Infectious: • Rheumatologic ... : SLE, Rheumatoid ... Arthritis, Sjogren Syndrome ... Disease, Behcet Syndrome ... Diagnosis #Causes #cardiology
LUMBAR Syndrome

What do you call a segmental lumbosacral hemangioma + spinal problems?? LUMBAR syndrome, a fairly
LUMBAR Syndrome ... LUMBAR syndrome, ... & Ulceration Myelopathy ... Consider when you see ... #Radiology #Diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... purpura, Arthralgia, Weakness ... diseases: - 10% SLE ... erythematosus (SLE ... classification #rheumatology
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
RASH + MUSCLE WEAKNESS ... Any inflammatory myopathy ... antisynthetase syndrome ... Severe proximal weakness ... IIMs #diagnosis #rheumatology