17 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... scleroderma) - Anti-Scl ... polyangiitis without renal ... Jcortesizaguirr #ANA #Antinuclear ... antibodies #diagnosis #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
Discoid Rash A Antinuclear ... Arthritis R Renal ... erythematosus #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Erythematosus - Summary Antinuclear ... severe disease & renal ... Summary #diagnosis #rheumatology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Renal involvement ... Mean eGFR - 39.5 mL ... /min • <60 mL/ ... TerrierBen #Renal ... Vasculitis #Management #Rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... Renal Disease, Liver ... Myelodysplasia #Anemia #MCV ... Algorithm #Causes #Hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
dL the ULN R - Renal ... /dL or CC < 40 ml ... M spike: • CML ... lymphoproliferative diseases, CML ... MGUS #diagnosis #hematology
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
concentration: > 750ng/mL ... probably < 1500ng/mL ... malabsorption) if < 200ng/mL ... Special cases (e.g. renal ... Measurement #SLE #rheumatology
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
pancreas, biliary, renal ... autoantibodies (antinuclear ... workup #treatment #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
disease (panuveitis, retinal ... aseptic meningitis), MCC ... involvement (uveitis or retinal ... Ocular: Giant retinal ... signs #symptoms #rheumatology