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diagnosis differential ana antibody hematology management algorithm anemia nuclear patterns testing anca antibodies antineutrophil antinxp2 antinxp2dm classification cytoplasmic dermatology dermatomyositis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... scleroderma) - Anti-Scl ... seen in 30—70% of cases ... Jcortesizaguirr #ANA #Antinuclear ... antibodies #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Scl70 (in some cases ... Smith, Sm/RNP, Scl ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Corpuscular Volume (MCV ... Renal Disease, Liver ... Diagnosis #Algorithm #Causes ... #Hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
probably < 1500ng/mL ... suspected) • In case ... • Special cases ... (e.g. renal failure ... Measurement #SLE #rheumatology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
dL the ULN R - Renal ... /dL or CC < 40 ml ... Causes of false- ... amyloidosis Other causes ... MGUS #diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Corpuscular Volume (MCV ... Reticulocytosis • Renal ... Diagnosis #Algorithm #Causes ... #Hematology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Scl70 (in some cases ... Smith, Sm/RNP, Scl ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
ab • RF • Antinuclear ... Hypocomplementemia • Can cause ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... Sjogrens #Syndrome #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
dorsal part of the MCP ... Muscle atrophy may cause ... • Clear cell renal ... diagnosis #management #rheumatology
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