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diagnosis lupus management ana antibody differential erythematosus systemic nuclear patterns syndrome testing algorithm anca anemia antibodies antineutrophil behcet causes cytoplasmic
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Discoid Rash A Antinuclear ... Arthritis R Renal ... #IMDAMNSHARP #sle ... erythematosus #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... scleroderma) - Anti-Scl ... Jcortesizaguirr #ANA #Antinuclear ... antibodies #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... severe disease & renal ... • Specific for SLE ... Erythematosus #SLE ... Summary #diagnosis #rheumatology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... probably < 1500ng/mL ... Special cases (e.g. renal ... #Measurement #SLE ... #rheumatology #
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Corpuscular Volume (MCV ... RA, SLE, PRV, Chronic ... Reticulocytosis • Renal ... Algorithm #Causes #Hematology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Homogeneous pattern: • SLE ... pattern: • SjS, SLE ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
disease (panuveitis, retinal ... Oral aphthae : SLE ... Ocular: Giant retinal ... • Arthritis: SLE ... signs #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... La, anti-Jo-1, SCL ... Erythematosus #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... Sjogrens #Syndrome #Rheumatology
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