15 results
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... : • Recurrent infections ... from neutropenia ... antibiotics if neutropenic ... management #treatment #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Causes of Neutropenia ... malignancies • Infection ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... #Differential #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... spherocytosis) • Infections ... #Causes #differential ... #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Hemolysis - Differential ... circulation - Infections ... immune-complex hemolytic anemia ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Difficulty breathing • Neutropenia ... - recurrent infections ... Idiopathic • Infections
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... Non-hemolytic: ACD, Aplastic ... Macroangiopathic, Infections ... MCV #Algorithm #Differential ... #Diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Vasculitis • Infection ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
marrow failure: Aplastic ... (e.g. cancer, infection ... G6PD deficiency), Infections ... Production #Index #hematology ... #anemia #differential
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
- Differential ... Megaloblastic anemia-rare ... white blood cell aplasia ... #differential # ... diagnosis #causes #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... drug induced • Infections ... #Differential # ... classification #hematology