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Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Acute febrile neutrophilic ... Neutrophilic dermatoses ... with systemic disease ... infiltrate of neutrophils ... may also show neutrophils
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
> 10% Band neutrophils ... than segmented neutrophils ... Band neutrophils ... in German) • Neutrophils ... • Autoimmune diseases
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
(Acute Febrile Neutrophilic ... Dense neutrophilic ... inflammatory disease ... 10^3/pL; >70% neutrophils ... Acute #Febrile #Neutrophilic
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... inflammation: Increased neutrophils ... cancers • Systemic diseases ... autoinflammatory diseases ... AdultOnset #Stills #Disease
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
of glomerular disease ... Majority anti-neutrophil ... CPR) cytoplasmic neutrophilic
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
the population Disease ... Autoimmune diseases ... Lymphoproliferative diseases ... Insect stings Disease ... (lymphocytes, neutrophils
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
macrophages, and neutrophils ... during hemolytic disease ... mediators and recruits neutrophils ... released from neutrophils
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Hypersegmented Neutrophils ... • Pancreatic Disease ... • Liver Disease
Diagnosis of Chronic Granulomatous Disease (CGD):
 - Neutrophil function tests (DHR123, NBT)
 - Genotyping confirmation

gp91phox is
Granulomatous Disease ... (CGD): - Neutrophil ... Granulomatous #Disease
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
appearing during the disease ... Neutrophilic dermatosis