18 results
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... ) MONOCLONAL CRYOGLOBULINEMIA ... necrosis • Pain ... #Rheumatology # ... Cryoglobulinemic
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
infectious mixed cryoglobulinemia ... < 5% of mixed cryoglobulinemia ... TerrierBen #NonHCV #Cryoglobulinemia ... #Vasculitis #Rheumatology ... #Mixed #Cryoglobulinemic
Treatment of Non-hepatitis C virus Cryoglobulinemia Vasculitis - French Vasculitis Study Group

MONOCLONAL CRYOGLOBULINEMIA (TYPE 1) 
IgM
Non-hepatitis C virus Cryoglobulinemia ... MONOCLONAL CRYOGLOBULINEMIA ... /or refractory disease ... #Vasculitis #Management ... #Rheumatology #
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
in 35% of mixed cryoglobulinemia ... • Type II cryoglobulinemia ... #Involvement #Cryoglobulinemia ... #Vasculitis #Management ... Cryoglobulinemic
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... , in Mixed Cryoglobulinemia ... Triad - Mixed Cryoglobulinemia ... • Autoimmune diseases ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ANCA +MPO) • Cryoglobulinemic ... purpura: strong sign ... , testes -> pain ... Low levels mixed cryoglobulinemia ... differential #diagnosis #rheumatology
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... (5%): PAN > GPA ... hemopathies (4%) • Cryoglobulinemia ... vasculitis (3%) ... dermatology #semiology #signs
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... Immunotactoid GN & Cryoglobulinemic ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic ... Sneddon-Wilkinson disease
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... Sensory and/or motor neuropathy ... tract: Abdominal pain ... / ANCA + MPO) Cryoglobulinemic ... Differential #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Butterfly rash, Vasculitis ... lesions Abdominal pain ... (20%) Renal disease ... erythematosus #signs ... symptoms #diagnosis #rheumatology