32 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Investigation of Abnormal ... Tests - Prolonged PT ... - Prolonged aPTT ... and Prolonged PT ... #Hematology #Diagnosis
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
to Evaluate an Abnormal ... the PT or APTT ... Prolonging the PT ... ISNeducation #Abnormal ... #diagnosis #hematology
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
(INR), Normal PTT ... , Normal PT (INR ... , Normal PT (INR ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
platelet count ... PT/INR • Normal ... aPTT (prolonged ... VonWillebrand #Disease #Diagnosis ... #Hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
ristocetin • Normal ... platelet, PT, PTT ... morphology — normal ... #disorders #hematology ... #differential #diagnosis
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal • ... Management #Algorithm #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
- Differential Diagnosis ... < 1800/uL, • platelet ... iron studies, PT ... /aPTT Differential ... #Algorithm #hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
an inhibitor of normal ... PT and/or aPTT) ... Mixing #Study #diagnosis ... #hematology #pathophysiology ... #hematology #laboratory
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Prothrombin Time (PT ... Prothrombin Time (PT ... inhibitor • Liver ... Thromboplastin #laboratory #hematology ... #diagnosis