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diagnosis algorithm sle erythematosus comparison dermatology management systemic vasculitis druginduced workup approach arthritis autoantibodies bleeding blood bruising classification clinical clues
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar rash ... - CRP: Usually normal ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... Hepatic, Portal, ... Inflammatory • Systemic Lupus ... Spleen #Enlarged #Differential ... #Hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... CRP - Usually normal ... Manifestations: Malar rash ... sle #comparison #table ... #rheumatology #
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... Autoimmune Vasculitis (lupus ... #Differential # ... #dermatology #physicalexam
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
muscle weakness, rash ... Elevated ESR, Normal ... muscle weakness • Normal ... Myopathies #myopathy #differential ... diagnosis #comparison #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... Nephropathy 16% - Oral ... (aPL) 30-45% Differential ... symptoms #mimickers #differential ... #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... everywhere) 2) A rash ... the face (many differential ... 6) An annular rash ... erythematosus #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... Idiopathic • Normal ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... flares • CRP normal ... Erythematosus #Diagnosis #Rheumatology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... o CML - bcr-able ... Amy Chung, MD, MSc ... Blood #Disorders #hematology ... #Markers #Differential
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