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diagnosis differential causes management algorithm treatment insufficiency medications hypocalcemia nephrology pharmacology hyperkalemia rhabdomyolysis secondary signs symptoms workup 21hydroxylasedeficiency 21ohd addisons
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Hypercalcemia ... Pseudohyperparathyroidism, Renal ... Immobilization Hypercalcemia ... calcium #high #endocrinology
Hypercalcemia - Differential Diagnosis Algorithm Primary Hyperparathyroidism • Adenoma • Hyperplasia • MEN 1 and 2A Tertiary Hyperparathyroidism
Hypercalcemia - ... Renal Failure, Post-Renal ... Hypocalciuria Hypercalcemia ... Immobilization • Adrenal ... Diagnosis #Algorithm #Endocrinology
CLINICAL MANIFESTATIONS OF ADRENAL INSUFFICIENCY. Primary and secondary adrenal insufficiency: - Tiredness, weakness, mental depression
MANIFESTATIONS OF ADRENAL ... and secondary adrenal ... hypoglycemia, mild normocytic ... Hyperpigmentation - Hyperkalemia ... insipidus #Adrenal
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... hypocalciuric hypercalcemia ... , adrenal, prostate ... Milk-alkali syndrome #Hypercalcemia ... #Causes #endocrinology
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia - ... Hypocalciuric Hypercalcemia ... Tumors: Lung, SCC, renal ... Thiazides/Lithium #Hypercalcemia ... Algorithm #causes #endocrinology
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... hypocalciuric hypercalcemia ... hormone–independent Renal ... thyrotoxicosis, adrenal ... Differential #Diagnosis #Endocrinology
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 Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Clinical Signs: • hyperCalcemia ... demineralization) • Renal ... nephropathy and hypercalcemia ... replacement) - Usually normocytic
Adrenal Insufficiency Differential Diagnosis Algorithm Clinical suspicion: Weakness, fatigue, nausea, musculoskeletal pain, dizziness, volume depletion, abdominal pain,
Adrenal Insufficiency ... hyponatremia, hyperkalemia ... ACTH - Primary adrenal ... ACTH - Secondary adrenal ... Diagnosis #Algorithm #endocrinology
Adrenal Insufficiency Diagnosis Algorithm Clinical features: - Weight loss, anorexia, Weakness, fatigue, GI distress - Hypotension,
Adrenal Insufficiency ... seen in PRIMARY adrenal ... Hyponatremia, hyperkalemia ... suggestive of adrenal ... Stimulation #StimTest #Endocrinology
Hyperkalemia - Differential Diagnosis - Impaired Excretion vs Redistribution Impaired Urinary Excretion - Renal failure -
Hyperkalemia - Differential ... Excretion - Renal ... DrEricStrong #Hyperkalemia ... Differential #Diagnosis #Table
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