78 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
pattern: - SLE ... pattern: - SjS, SLE ... : - SLE, SjS, ... conditions, SjS, SLE ... , SjS, RA, OSs,
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus ... lupus nephritis ... (90%) Anti-SSA ... , neonatal lupus ... neonatal lupus
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... (SLE): ANA (anti-nuclear ... Anti-Smith, Anti-Ro (SSA ... glycoprotein I (ß2GP), Lupus ... Syndrome: Anti-Ro (SSA
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... , Drug-induced Lupus ... erythematosus (SLE ... erythematosus (SLE
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Workup: - ANA ... - Rare (SSA+ for ... Workup: - ANA ... #sle #comparison
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... activity Anti-Ro/SSA ... Ann Marie Kumfer ... #Systemic #Lupus
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
involvement 3% SLE-Related ... Auto-Antibodies: - ANA ... 60-70% - Anti-SSA ... Differential Diagnosis and ... Lupusreference #SLE
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... lesions • Anti-Ro/SSA ... Serositis Labs: • ANA ... + (+) anti-Ro/SSA
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Influenza, EBV, PNA ... valves, COPD, ILD, OSA ... body-), PMR, RA, SLE
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus (SLE ... , Drug-induced Lupus ... erythematosus (SLE ... erythematosus (SLE ... (SLE), Systemic