19 results
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
critically ill pregnant ... schistocytes, DIC ... child * Severe cases ... #HELLP #AFLP #Obstetrics ... #OBGyn #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Fatty Liver of Pregnancy ... schistocytes, DIC ... child * Severe cases ... #HELLP #AFLP #obstetrics ... #hematology #diagnosis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Fatty Liver of Pregnancy ... (AFLP) Pathophysiology ... = nonspecific (nausea ... rapidly develops (DIC ... #hepatology #obstetrics
Nausea and Vomiting in Pregnancy: Hyperemesis Gravidarum vs Nausea and Vomiting of Pregnancy

Diagnosis, Workup and Treatment

#Diagnosis
in Pregnancy: Hyperemesis ... and Vomiting of Pregnancy ... #Diagnosis #Management ... #OBGyn #Obstetrics ... Hyperemesis #Gravidarum #Pregnancy
Post-abortion Hemorrhage Management Algorithm
Cervical laceration
 → Direct pressure, silver nitrate for small laceration
 → Repair with
Post-abortion Hemorrhage Management ... atony or unsure of cause ... Repeat D&C Ectopic pregnancy ... coagulopathy or DIC ... #Algorithm #obstetrics
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in Pregnancy ... Cholestasis of Pregnancy ... Fatty Liver of Pregnancy ... DIC • Aminotransferases ... #hepatology #obstetrics
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Microangiopathy: DIC ... antiphospholipid syndrome - Pregnancy ... Diagnosis #Framework #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
ED Treatment of 
Abnormal Uterine Bleeding 

Hemodynamically unstable 
Resuscitation 
 • ABCs! 
 • Fluids +
coagulopathy Pregnancy ... possible ectopic vs pregnancy ... related cause ... Uterine #Bleeding #Management ... #Obstetrics #Gynecology
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... children, so I did ... transplant, infection, pregnancy ... Microangiopathy #TMAs #hematology