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management algorithm hemolysis workup causes thrombocytosis agglutinin antibody apml arteritis autoimmune cancer chronic classification cll cold differentiation disease dyspnea gca
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... #Hemolytic #Anemia ... #Algorithm #Differential ... Causes #Workup #Hematology ... GrepMed Recommended Text
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... TMA after solid organ ... anemia" • HELLP ... #schistocytes #differential ... #diagnosis #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... • Blood smear: Differential ... #Anemia #diagnosis ... #management #treatment ... #rheumatology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... infection • Solid organ ... malignancies • Anemia ... iron deficiency, hemolysis ... #hematology #secondary
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Defects: Sickle cell anemia ... Laboratory Tests ... Diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Diagnosis Algorithm ... blood loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... younger pts) Differential ... Test: Donath-Landsteiner ... test #cold # ... #anemia #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
value is low, tests ... result in severe anemia ... anemia Indirect ... WBC count and differential ... #Workup #Hematology
Dyspnea - Considerations with Malignancy Directly Malignancy Related: - Lymphangitic spread to lung - Malignant pleural effusion
metastases Treatment ... - Cytopenias (anemia ... Changes in Pre-Test ... dyspnea #algorithm #differential ... #diagnosis #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... initiation • Differential ... Renal Failure Treatment ... #management #hematology ... #oncology
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