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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Systemic Lupus Erythematosus ... #SLE #hematology ... #rheumatology # ... differential #diagnosis ... #causes
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
(SLE) #Systemic ... #SLE #Manifestations ... #Signs #Symptoms ... #Rheumatology # ... Diagnosis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Vesicopustule on erythematous ... Antiphospholipid-antibody syndrome ... Discoid lupus erythematosus ... #differential #diagnosis ... #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
(SLE), Sjogren's ... Syndrome (SS), ... (SLE), Systemic ... ANA #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Systemic #Lupus #Erythematosus ... diagnosis #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... - Differential Diagnosis ... Systemic Lupus Erythematosus ... #Algorithm #Causes ... #Hematology #Oncology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Positive in 60-80% of cases ... #Diagnosis #Management ... #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... #rheumatology #
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Systemic Lupus (SLE ... Demyelinating syndromes ... #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... arteritis, Cogan's Syndrome ... Systemic lupus erythematosus ... (SLE), Sarcoidosis ... #rheumatology