100 results
Bone resorption and the relationship between osteoblasts and osteoclasts.  
RANK is expressed on the osteoclasts,
Bone resorption ... the surface of bone ... from the adjacent bone ... which results in bone ... #Osteoclasts #Bone
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... -> Incr Osteoclasts ... -> Reduced Bone ... Formation, Increased Bone
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... IGFIR activates osteoblasts ... GrowthHormone #GH #FeedbackLoop
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... forms bony callus ... mos - yrs) • Osteoclast-osteoblast ... coupled bone remodeling ... from GI tract, bone
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Differential Diagnosis Algorithm ... Miscellaneous - Bone ... Hyperthyroid, Bony ... Differential #Diagnosis #Algorithm
Pancytopenia - Differential Algorithm / Schema

- Bone Marrow Failure
- Bone Marrow Infiltration
- Sequestration / Destruction

#Pancytopenia #Differential
- Differential Algorithm ... / Schema - Bone ... Marrow Failure - Bone ... #Differential #Algorithm
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Differential Diagnosis Algorithm ... production: • Bone ... suppression • Bone ... marrow failure • Bone ... Differential #Diagnosis #Algorithm
Bisphosphonates for Osteoporosis Treatment or Prevention 

Bisphosphonates are common medications used in the treatment and prevention
Bisphosophonates inhibit osteoclasts ... turn increase bone
Bone Lesion on X-Ray - Differential Diagnosis Algorithm 
Exostotic
 • Osteochondroma
Asymptomatic &/or Non-Active Bone Scam
 •
Bone Lesion on X-Ray ... Differential Diagnosis Algorithm ... /or Non-Active Bone ... • Unicameral Bone ... Differential #Diagnosis #Algorithm