2729 results
Pharmacologic Options for Hypercalcemia Associated with Cancer
Rehydration with NS followed by loop diuretics
 • IV normal
acid - Inhibits osteoclast ... RANKL to decrease osteoclast ... nitrate - Inhibits osteoclast ... #medications #management
Bisphosphonates for Osteoporosis Treatment or Prevention 

Bisphosphonates are common medications used in the treatment and prevention
Bisphosophonates inhibit osteoclasts ... #Osteoporosis #Management
Bone resorption and the relationship between osteoblasts and osteoclasts.  
RANK is expressed on the osteoclasts,
relationship between osteoblasts ... and osteoclasts ... expressed on the osteoclasts ... RANK stimulates osteoclast ... #Osteoclasts #Bone
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... expression of osteoclasts ... -> Incr Osteoclasts
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
IGFIR activates osteoblasts
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... mos - yrs) • Osteoclast-osteoblast ... gentamycin - Toxic to osteoblasts
Pain Assessment and Management Initiative (PAMI) - Pain Management and Dosing Guide

#Management #Pain #Pharmacology #Doses #Dosing
Assessment and Management ... (PAMI) - Pain Management ... Dosing Guide #Management
Acute Kidney Injury - Differential Diagnosis Framework
PRERENAL:
 - Intrarenal vasoconstriction-hemodynamically mediated
 - Systemic vasodilation
 - Volume
urinalysis, labs - Management ... renal biopsy - Management ... ultrasonography - Manaqement
Diabetic Ketoacidosis - Diagnosis and Management Checklist
Diagnosis
Investigations
Phase 1 Management
Phase 2 Management
Phase 3 Management
Special measures
Subsequent Management

#Diabetic #Ketoacidosis
Diagnosis and Management ... Investigations Phase 1 Management ... Phase 2 Management ... Phase 3 Management ... DKA #Diagnosis #Management