30 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Differential Diagnosis Algorithm ... Signs of anemia ... Hypersplenism, Infection ... Matthew Ho, MD PhD ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... differential #diagnosis #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... Macroangiopathic, Infections ... aciduria, Drugs (e.g ... Matthew Ho, MD PhD ... Differential #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... Differential Diagnosis Algorithm ... circulation - Infections ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... → Refer to hematology ... blood loss, Acute hemolysis ... Matthew Ho, MD PhD ... #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... Steroids - 1-2 mg/kg ... > 10, no more hemolysis ... Polyclonal: - Infection ... Treatment #management #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Differential Diagnosis Algorithm ... • Thrombus (e.g ... Serum Sickness Hemolytic ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Differential Diagnosis Algorithm ... • Secondary (e.g ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... #Causes #Hematology
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Differential Diagnosis Algorithm ... infiltration • Infection ... Matthew Ho, MD PhD ... Differential #Diagnosis #Algorithm ... #hematology #platelets
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... inclusions - If infection ... Differential #Diagnosis #Algorithm ... #workup #hematology