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diagnosis hematology algorithm causes management clinical disorders electrocardiogram neurology thrombocytopenia treatment cardiomyopathy classification embolism endocarditis infectiousdiseases mcv peripartum stemi thrombocytosis
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Diagnosis Algorithm Signs ... of anemia and hemolysis ... Matthew Ho, MD PhD ... #Anemias #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... Extravascular #Causes #differential
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... , CKD • Hemolytic ... aciduria, Drugs (e.g ... Matthew Ho, MD PhD ... #Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g ... Marrow suppression (e.g ... Microangiopathic hemolytic ... RBC defects (e.g ... #anemia #differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... • Secondary (e.g ... Bleed • Hemolysis ... #Differential # ... Algorithm #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... • Bleeding • Hemolysis ... Chronic Disease (e.g ... Inflammation, Chronic Infection ... Algorithm #Causes #Hematology
Pulmonary Embolism on POCUS Echocardiogram Mid 30's female with chest pain/dyspnea. Triage EKG (no prior).
Triage EKG (no prior ... Sister had MI in ... Differential/diagnosis ... RV, McConnell's sign ... A4c #clinical #cardiology
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 Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... malignancies • Anemia ... iron deficiency, hemolysis ... inflammatory disorders (e.g ... Diagnosis #Causes #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Vasculitis • Infection ... Foreign Surface (e.g
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Microangiopathic Hemolytic ... Cold autoimmune hemolytic ... RBC #Morphology #differential ... #diagnosis #hematology
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