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differential hematology management workup classification dermatology macrocytic macrocytosis disorders elevatedmcv elevation generalized injury leukemia mds microcytic myelodysplastic pruritus secondary syndrome
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... Loss • Acute ... Deficiency • Aplastic ... #Algorithm #Causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Algorithm Decreased ... • Marrow Aplasia ... Normal RBCs • Acute ... #Algorithm #Causes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... result from low blood ... #Anemia #oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
the peripheral blood ... marrow failure: Aplastic ... Index > 3: • Acute ... blood loss: Trauma ... #differential #diagnosis
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... turnover • Acute ... blood loss • ... Hemolytic anemia ... Increase #Decrease #Diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Algorithm Reactive ... Fatigue • Acute ... #Algorithm #Causes ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute ... treatment #hematology #oncology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... - Differential Diagnosis ... Algorithm Decreased ... : Chronic Blood ... #Algorithm #Causes
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Algorithm Mean ... in peripheral blood ... High in acute blood ... #Algorithm #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Artifact (redo CBC ... Infectious: • Acute ... Iron deficiency anemia ... #Algorithm #Causes
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