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hematology differential causes management leukemia syndrome treatment workup acidosis anemias approach blood calculation chestpain chronic cll dermatology diffuse disease disorders
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Expectation • Rx Algorithm ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... Loss • Acute ... Deficiency • Aplastic ... #Classification
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... Algorithm Decreased ... • Marrow Aplasia ... Normal RBCs • Acute ... #Algorithm #Causes
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... • Extrinsic RBC ... #Differential #Diagnosis ... #Algorithm #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Diagnosis: • Pancytopenia ... progress to MDS or acute ... #Anemia #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... • ↓ WBC • ↓ ... #Anemia #oncology ... #hematology #diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... Diagnosis Framework ... Non-hemolytic: ACD, Aplastic ... Spherocytosis, G6PD, PK, HbC ... #MCV #Algorithm
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute ... treatment #hematology #oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... marrow failure: Aplastic ... Index > 3: • Acute ... , Intrinsic RBC ... #differential #diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... Algorithm Reactive ... Fatigue • Acute ... #Algorithm #Causes ... #Hematology #Oncology
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