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hematology differential management syndrome algorithm causes leukemia treatment workup apml approach calculation chronic classification cll dermatology differentiation diffuse disease erythematosus
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Diagnosis: • Pancytopenia ... progress to MDS or acute ... #Anemia #diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Blood Loss • Acute ... Deficiency • Aplastic ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... • Marrow Aplasia ... Normal RBCs • Acute ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... • ↓ WBC • ↓ ... #Anemia #oncology ... #hematology #diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... • Rheumatoid Arthritis ... Fatigue • Acute ... #Differential #Diagnosis ... #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute ... Management #treatment #hematology ... #oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... marrow failure: Aplastic ... Index > 3: • Acute ... Production #Index #hematology ... #diagnosis #calculation
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... • Rare: DAH, acute ... , Anaphylaxis, Acute ... #management #hematology ... #oncology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... , erythema and WBC ... noninflammatory Signs ... #Differential #Diagnosis ... #MSK #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - ACS, AKI, acute ... >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
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