28 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... Ill • ANCA Vasculitis ... : P-ANCA (perinuclear ... ), C-ANCA (cytoplasmic ... #table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Antibody) and ANCA ... in drug-induced SLE ... Jcortesizaguirr #ANA ... #antibodies #diagnosis ... #rheumatology #
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Disease Associations ANA ... Graves' disease c-ANCA ... granulomatosis p-ANCA ... Associations #diseases #diagnosis ... #table #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
D Discoid Rash ... A Antinuclear Antibody ... (ANA) M Mucositis ... Pleuritis) H Hematologic ... #IMDAMNSHARP #sle
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... #differential #diagnosis ... #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... Discontinuation of causal ... Workup: - ANA ... #comparison #table ... diagnosis #management
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
pleurisy (search ANA ... person (search ANA ... cytopenia (search ANA ... including in children (pediatric ... #sle #clues #system
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Manifestations: Malar rash ... Workup: - ANA ... Positive in 60-80% of cases ... Erythematosus #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... causes arthritis ... mucositis - Rash ... SLE) • Urinalysis ... #rheumatology #
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... 3rd Decade Skin ... : • ANCA-associated ... Serositis Labs: • ANA ... antibodies • (-) ANA