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differential management comparison erythematosus sle workup algorithm anemia dermatology systemic antibodies antinuclear autoantibodies hemolytic oncology treatment vasculitis aflp associations classification
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... uremic syndrome ... usually IgG) (e.g. lupus ... #hematology #anemia
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... #Workup #Hematology ... #Diagnosis * ... GrepMed Recommended Text
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Diagnosis Algorithm ... Cold AIHA • PCH ... #Algorithm #Causes ... #Hematology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... NEUROLOGIC - HEMOLYTIC ... Direct Coombs’ test ... anemia #Diagnosis ... #Rheumatology #
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Wiskott-Aldrich syndrome ... Inflammatory and ... Diseases: • Systemic lupus ... Antibody-mediated hemolysis ... #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
defects. 1) HELLP (Hemolysis ... Elevated Liver tests ... child * Severe cases ... AFLP #obstetrics #hematology ... #diagnosis #table
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Drug-associated, PCH ... , Evans Syndrome ... Laboratory Tests ... #hematology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... defects. 1) HELLP (Hemolysis ... Elevated Liver tests ... Obstetrics #OBGyn #Hematology ... #Table
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... Test: Donath-Landsteiner ... test #cold # ... #anemia #hematology
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