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management oncology thrombocytopenia causes differential hemeonc hemophagocytic hlh lupus lymphohistiocytosis sle workup aplastic apml arteritis autoimmune cell cerebritis cns coagulation
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Autoimmune Hemolytic Anemia ... Spherocytes • Treatment ... transient hemolysis • Treatment ... #hematology #diagnosis ... #comparison
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
distinction has HUGE treatment ... and first-line treatment ... thrombocytopenia #Comparison ... #Diagnosis #Table ... #Hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
: 33% • Treatment ... : No • Treatment ... Transfusion #Reactions #hematology ... #diagnosis #comparison ... #table
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... #Differential #Diagnosis ... Causes #Workup #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... permeability Diagnosis ... Erythematosus #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • ↓ WBC • ↓ PLT ... Treatment: ... #oncology #hematology ... #diagnosis #management
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
♀, ↑Age, ESRD Pathophysiology ... heparin-PF4 complex → plt ... hypercoagulable state and plt ... #Management #Treatment ... #Hematology #HemeOnc
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... Renal Failure Treatment ... fluid overload, PCC ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Cytopenia +++ (Plt ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... + Bleeding Treatment ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
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