18 results
differential testing treatment antibody antinuclear comparison mds myelodysplastic nuclear patterns syndrome altered ams anemia antibodies aplastic associations autoantibodies autoimmune challenges
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
: - PBC, SSc ... , PBC/SSc OS, PBC ... ARUPConsult @ARUPLabs #ANA ... #differential #diagnosis ... #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... fluid overload, PCC ... Differentiation #Syndrome #APML ... #diagnosis #management ... #hematology #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
and Management ... old, ~10,000 new cases ... acute leukemia Management ... #Management #treatment ... #hematology #oncology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Disease Associations ANA ... biliary cirrhosis (PBC ... Associations #diseases #diagnosis ... #table #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
: Blast crises ... count • ↓Hg & PLT ... smear: Blasts APML ... #Leukemia #Hematology ... #Oncology #Diagnosis
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
pattern: • SSc, PBC ... dots pattern: • PBC ... conditions • Sp-100, PML ... #differential #diagnosis ... #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Cytopenia +++ (Plt ... Drugs, Unknown cause ... #management #treatment ... #summary #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Treat primary cause ... abnormalities - PLT ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... Usual therapeutic management ... sle #comparison #table ... #rheumatology # ... diagnosis #management
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