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differential hematology treatment antibody antinuclear patterns testing abscess aih anemia antibodies aplastic apml associations autoantibodies classification cytoplasmic differentiation diseases gap
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - PBC ... : - PBC, SSc ... , PBC/SSc OS, PBC ... #differential #diagnosis ... #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... Associations #diseases #diagnosis ... #table #rheumatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... reported (eg AIH-PBC ... Autoantibodies: Auto-Nuclear ... BryanCUlrich #Autoimmune ... #Management #Hepatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
pattern: • SSc, PBC ... : • PBC, DM, other ... ARUPConsult @ARUPLabs #ANA ... #differential #diagnosis ... #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
opacities • Diagnosis ... • Differential Diagnosis ... fluid overload, PCC ... #management #hematology ... #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... solid cancers • Autoimmune ... Drugs, Unknown cause ... #management #treatment ... #summary #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... #differential #diagnosis ... #hematology
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
and Management ... • Most common cause ... of PCN allergy ... residual lesion or is clear ... #differential #causes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
petechiae Causes ... • ↓ WBC • ↓ PLT ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
and Management ... Antibiotics (Bactrim, PCN ... cause) Management ... Elimination (see Table ... and management
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