12 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... pattern: - PBC ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... Cytoplasmic #Patterns #differential
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... • Blood smear: Differential ... 2) LOOK FOR a cause ... Anemia #diagnosis #management ... #treatment #rheumatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
) - Summary PBC ... 30-65 years PBC ... Pathophysiology ... intralobular bile ducts causes ... bile ducts Differential
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Pathophysiology ... initiation • Differential ... fluid overload, PCC ... APML #diagnosis #management ... #hematology #oncology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... #pathophysiology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody ... pattern: • SSc, PBC ... dots pattern: • PBC ... Nuclear #Patterns #differential ... #diagnosis #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... + Bleeding Treatment ... Treat primary cause ... #treatment #management ... #hematology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... of PCN allergy ... Lung Abscess Differential ... Abscess #pulmonary #differential ... #causes #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Cytopenia +++ (Plt ... Treatment: • ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... www.ncbi.nlm.nih.gov/pmc ... / hypoxemia -> focus ... perfusion - shock->treatments ... before beginning treatment