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diagnosis differential management hemolysis intravascular oncology algorithm extravascular rheumatology agglutinin alkaline alp autoimmune cirrhosis coagulation cold common cvid dermatology dic
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... #Autoimmune #Hemolytic ... #Anemia #Pathophysiology ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • PCH • PNH ... anemia • ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... hemoglobinuria (PNH ... differential #diagnosis #hematology ... #anemia
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... Hypersplenism • AIHA ... #classification ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Diagnosis Algorithm Low ... • Bleeding • Hemolysis ... #MCV #Classification ... #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA ... Liver Disease, PNH ... Defects: Sickle cell anemia ... Differential #Diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... originate from a low-grade ... • Symptoms of anemia ... anemia • Cold ... #anemia #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
protease activity - A low ... If the value is low ... result in severe anemia ... anemia Indirect ... Diagnosis #Workup #Hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Cardiovascular Causes ... fast - Too slow ... - Water - Pus ... Transverse myelitis • Hematology ... : - Anemia •
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Causes of Anemia ... Diagnosis Framework LOW ... , Autoimmune hemolytic ... anemia, Hemolysis ... Differential #Diagnosis #Hepatology
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