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diagnosis differential lupus management sle systemic ana antinuclear associations diseases vasculitis anca antibody antineutrophil antinxp2 antinxp2dm arterial autoimmune cerebritis classification
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Rheumatology • ... others (RNP, aPL antibodies ... #Rheumatology # ... #associations #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... #Autoantibodies ... diseases #diagnosis #table ... #rheumatology # ... antibodies
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Demyelinating Syndrome ... the formation of autoantibodies ... that will cause ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... Non-autoimmune rheumatologic ... lower extremity edema ... • May involve PNS ... #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Systemic lupus erythematosus ... • Sjögren syndrome ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... SLE-SSc-AlM overlap syndromes ... #Antinuclear #autoantibodies ... #diagnosis #rheumatology ... #table #ANA
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... Antiphospholipid antibodies ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... months) and of autoantibodies ... Systemic Lupus Erythematosus ... sle #comparison #table ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... • Antinuclear antibodies ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... #Rheumatology #
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Pts have more ... without these autoantibodies ... • Antibodies targeting ... Muscle atrophy may cause ... diagnosis #management #rheumatology
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