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diagnosis differential treatment dermatology lupus sle comparison systemic disease oncology vasculitis pharmacology thrombocytopenia aflp anemia antinuclear cardiology classification dermatomyositis dress
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Demyelinating Syndrome ... autoantibodies that will cause ... #rheumatology # ... cerebritis #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... lower extremity edema ... • May involve PNS ... and CNS • Headache ... #Diagnosis #Rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... Systemic Lupus Erythematosus ... Ann Marie Kumfer ... #differential #hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... block • Sjogren syndrome ... Summary #diagnosis #rheumatology ... #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Workup: - ANA ... Positive in 60-80% of cases ... lupus #Systemic #Erythematosus ... #Summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... nervous system (CNS ... systemic lupus erythematosus ... #Diagnosis #Management ... #Hematology #Rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... deficiencies - PNH ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology ... #rheumatology #
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
arteritis, Cogan's Syndrome ... Nodosa (PAN), ANCA ... Systemic lupus erythematosus ... (SPA) • Other Causes ... Differential #Diagnosis #rheumatology
DRESS Syndrome vs SJS/TEN DRESS • Latency: 2-8 weeks • Rash: Morbilliform • Mucosal involvement: 50% have
DRESS Syndrome vs ... biopsy: Dermal edema ... Rash: Painful erythematous ... TEN #comparison #table ... #dermatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Systemic lupus erythematosus ... seen in 30—70% of cases ... • Sjögren syndrome ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology
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