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Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... and Intravascular ... • PCH • PNH ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - Intravascular ... Causes Intravascular ... hemoglobinuria (PNH ... #Causes #differential ... #diagnosis #hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... - Disseminated intravascular ... APLS:PLT ↓ HEMATOLOGIC ... neoplasms - PNH
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Anemia Intrinsic Causes ... elliptocytosis Extrinsic Causes ... IVIG infusion Intravascular ... Causes: • MAHA ... classification #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... • Disseminated Intravascular ... Diagnosis #Algorithm #Causes ... #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Treat primary cause ... #Disseminated #Intravascular ... Coagulation #diagnosis #causes ... treatment #management #hematology
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
URT inflammation causes ... replicates within CNS ... invade URT & via hematologic ... induces vascular & CNS ... CNS and hematologic
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
considered in all cases ... - Disseminated intravascular ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Cardiovascular Causes ... Tamponade Pulmonary Causes ... - Water - Pus ... syndrome Other Causes ... Transverse myelitis • Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disorders, or other causes ... • Secondary Causes ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #rheumatology #
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