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diagnosis differential treatment arterial extravascular hemolysis thrombosis venous algorithm anemia antinxp2 antinxp2dm cerebritis clots cns coagulation dermatomyositis dic disseminated embolism
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... and Intravascular ... • PCH • PNH ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - Intravascular ... Causes Intravascular ... hemoglobinuria (PNH ... #Causes #differential ... #diagnosis #hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... - Disseminated intravascular ... neoplasms - PNH ... Diagnosis #clots #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Treat primary cause ... #Disseminated #Intravascular ... #treatment #management ... #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #neurology #rheumatology ... cerebritis #diagnosis #management
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
considered in all cases ... - Disseminated intravascular ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... Rule out other causes ... SAPHO #Syndrome #Rheumatology ... #diagnosis #management ... #Dermatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
(depending on CNS ... steroids • In mild cases ... Options for severe cases ... HLH #Treatment #management ... #hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
subcutaneous edema Pts ... Muscle atrophy may cause ... Dermatomyositis #diagnosis #management ... #rheumatology # ... dermatology
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