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diagnosis management syndrome chronic lymphocytic mds myelodysplastic rheumatology 1 acute algorithm all anemia anthracycline aplastic apml cancer cardiomyopathy cardiotoxicity cdi
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... ALL (Acute Lymphoblastic ... -> AML: Blast crises ... Transformation: • Complication ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... ’s lymphoma or acute ... leukemia #CLL ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... transformation to acute ... leukemia Management ... Allogeneic stem cell ... #hematology #oncology
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
for Standard-Risk ... Consolidation & CNS ... Cytarabine #ALL ... #Leukemia #Treatment ... #timeline #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... thrombocytopenia Complications ... chemotherapy for low-risk ... uw_IMresidency #CLL ... #oncology #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Consider stem cell ... neutropenic fever) Complications ... progress to MDS or acute ... leukemia • Associated ... #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Sweet Syndrome Acute ... general feeling of ill ... Causes: - Idiopathic ... Treatment: - Systemic ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
carries a variable risk ... Leukemia • Idiopathic ... and reducing the risk ... Syndromes #diagnosis #hematology ... #oncology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... promyelocytic leukemia ... Treat primary cause ... #treatment #management ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... • Induce blast cell ... Attempt if high risk ... diagnosis #management #hematology ... #oncology
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