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differential hematology management classification polycythemia pulmonary workup ana antibodies antibody anticoagulation antineutrophil antinuclear aortitis bleeding breakthrough bruising cryofibrinogenemia cryoglobulinemia cryoglobulins
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
seen in 30—70% of cases ... Vasculitis: • ... Renal-limited vasculitis ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... (C-ANCA): GPA > ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
ANCA-Associated Vasculitis There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated ... Vasculitis There ... StanfordChiefs #ANCA ... #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... Differential Diagnosis ... differential #diagnosis ... #rheumatology #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... • Secondary Causes ... Cryoglobulinemia (MIXED) • ANCA ... #Differential #Diagnosis ... #hematology #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Inflammatory Conditions: Rheumatologic ... , Vasculitides, ... Matthew Ho, MD PhD ... #Algorithm #hematology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... Nodosa (PAN), ANCA ... associated vasculitis ... #Differential #Diagnosis ... #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential Diagnosis ... HUS • DIC • Vasculitis ... #Algorithm #Causes ... #Hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Differential Diagnosis ... - Water - Pus ... Pulmonary HTN - Vasculitis ... Transverse myelitis • Hematology ... #differential #diagnosis
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
- Differential Diagnosis ... Algorithm • 12 ... -13 g/dL, • ANC ... Matthew Ho, MD PhD ... #Algorithm #hematology
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