15 results
diagnosis algorithm hemolysis atlas causes extravascular intravascular management microscopy morphology rbc agglutinin aiha analysis anemias antibody bandemia blood bloodcell calculation
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
bilirubin • ↑ Reticulocytes ... Abnormal peripheral smear ... : • Autoimmune ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood Smear ... Microspherocytes: Autoimmune ... hemolytic anemia ... #Analysis #hematology ... interpretation #clinical
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... or negative - Smear ... #Hemolytic #Anemia ... #diagnosis #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... C3d • Blood smear ... : Differential → ... #Hemolytic #Anemia ... management #treatment #rheumatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Hemoglobin Defects: Sickle ... Peripheral Blood Smear ... Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
: Autoimmune, Microangiopathic ... hemolytic anemia ... defects (e.g. sickle ... Production #Index #hematology ... #anemia #differential
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
syndrome, Increased reticulocyte ... spherocytosis, Hemolytic ... - Sickle cell anemia ... key #diagnosis #differential ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... Hemoglobinopathies (e.g. sickle ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Cold AIHA • Alloimmune ... Thalassemia • Sickle ... anemia • ... Algorithm #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... elliptocytosis, autoimmune ... #Anemia #Differential ... Algorithm #workup #hematology
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