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differential sle syndrome anemia bleeding bruising dermatology disease druginduced erythematosus intravascular systemic activation aplastic arterial arteritis capillary cardiology cerebritis clarksons
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Algorithm Thrombocytopenia ... • Steroids • Vasculitis ... #Algorithm #Causes ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... inflammation • Thrombocytopenia ... : - Thrombocytopenia ... #Differential #Diagnosis ... #hematology #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential Diagnosis ... HUS • DIC • Vasculitis ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... effect following treatment ... following EtOH induced thrombocytopenia ... #Algorithm #Causes ... #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
+ Bleeding Treatment ... Treat primary cause ... #diagnosis #causes ... #treatment #management ... #hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... With associated pulmonary ... #differential #diagnosis ... #algorithm #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... hemostasis: - Thrombocytopenia ... (lupus, RA, Sjogren's ... Complete blood count coagulation ... #Algorithm #Causes
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group < 5%
- Diagnosis, causes ... and management ... neuropathy Treatment ... #Rheumatology # ... #Management
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... #hematology #anemia
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Positive in 60-80% of cases ... life-threatening • Treatment ... Erythematosus #Diagnosis ... #rheumatology
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