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hematology management antiphospholipid differential guidelines hypercoagulable rheumatology workup anticoagulation apml arterial cerebritis cns differentiation embolism erythematosus essential et eular2019 hemolysis
Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
(APS) APS is a ... or small-vessel thrombosis ... 1 of the three aPLs ... to be present Treatment ... #APS #diagnosis
2019 EULAR recommendations for thrombosis in (Antiphospholipid Syndrome) APS Venous Thrombosis - Arterial Thrombosis INR Target Duration Recurrence Dr. Laurent ARNAUD
Antiphospholipid Syndrome ... ) APS Venous Thrombosis ... #APS #management ... #rheumatology #hematology ... #treatment
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
imaging → Test for APS ... actor for arterial thrombosis ... Inherited and APS ... Inherited and APS ... #diagnosis #algorithm
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Venous Thrombosis ... - Differential Diagnosis ... Hyperviscosity, TTP, APLS ... • Nephrotic Syndrome ... Antiphospholipid antibodies (APLS
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... hemolysis: • Thrombotic ... hemolytic-uremic syndrome ... • Catastrophic APLS ... #hematology #hemolysis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Triggers: ATRA treatment ... Renal Failure Treatment ... unless severe APLS
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... vasculopathy, thrombosis ... permeability Diagnosis ... (for secondary APS ... #management #treatment
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid Syndrome ... (APLS) Testing ... episodes of arterial, venous ... ARUPConsult @ARUPLabs #APLS ... #diagnosis #hematology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... 10 minutes of rest ... HPS Diagnostic ... ) on room air Treatment ... #treatment #hepatology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Splenomegaly Diagnosis ... • Treatment algorithms ... (if history of venous ... thrombosis) ... #hematology
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