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differential rheumatology erythematosus systemic causes management algorithm classification oncology arthritis pediatrics peds purpura signs symptoms testing thrombocytopenia activation approach autoantibodies
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... ANEMIA - LEUKOPENIA ... anemia #Diagnosis ... #Rheumatology # ... SLE #Lupus #Erythematosus
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... usually IgG) (e.g. lupus ... #differential #diagnosis ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... ): SS, SC, SE, Sβ ... #Anemia #Differential ... #workup #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... involvement 3% SLE-Related ... Lupusreference #SLE ... #differential #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... pericarditis • Hematologic ... Thrombocytopenia, Autoimmune hemolysis ... #SLE #Systemic ... #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: ... pain (20%) Renal disease ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis ... #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... : • Systemic lupus ... Antibody-mediated hemolysis ... #Hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... Evolution: Chronic disease ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Vasculitides, IBD, Celiac disease
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... Evolution: Chronic disease ... #table #rheumatology ... #diagnosis #management
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