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differential management anemia peds disorders msk systemic treatment workup bleeding bruising classification constipation dermatology disease elevatedmcv endocrinology erythematosus jointpain lupus
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... #hematology #anemia
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
• Thrombus (e.g ... Myeloproliferative disorders (eg ... Serum Sickness Hemolytic ... #Algorithm #Causes ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Algorithm Decreased ... • Secondary (e.g ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... Foreign Surface (e.g ... #Algorithm #Causes ... #Hematology
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
- Differential Diagnosis ... Algorithm Pre-Hepatic ... Production • Hemolysis ... Sepsis • Drugs (e.g ... #Algorithm #Causes
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... iron deficiency, hemolysis ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... #Causes #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... - Differential Diagnosis ... -100): • Non-hemolytic ... aciduria, Drugs (e.g ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Chronic Disease (e.g ... #Algorithm #Causes ... #Hematology
Causes of Pediatric Constipation - Differential Diagnosis Algorithm Dietary / Functional: • Insufficient Volume / Bulk Neurologic: •
Causes of Pediatric ... Algorithm Dietary ... Withholding • Painful (e.g ... Guillain-Barré Syndrome ... #Algorithm #Causes
Causes of Developmental Delay - Differential Diagnosis Algorithm Isolated Domain Delay - Reduced Respiratory Drive: • Cognitive
Causes of Developmental ... Teratogenic Disorder (e.g ... • Mechanical (e.g ... #Algorithm #Causes ... #Peds #Pediatrics
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