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causes oncology algorithm thrombocytosis cll lymphocytic management anemia bruising calculation classification diffuse enlarged hemeonc hodgkins index isolated lad lupus lymphadenopathy
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Cancer: • Leukemia ... Inflammatory and Autoimmune ... Systemic lupus erythematosus ... deficiency Infections ... #Diagnosis #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... Systemic Lupus Erythematosus ... Pseudotumor - Infectious ... Age > 50 • Chronic ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute infection ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... myeloid leukemia ... #hematology #secondary
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Myelogenous Leukemia ... Myelofibrosis Infectious ... effect following treatment ... #Causes #Hematology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
- Differential ... Antineoplastic Viral Infection ... Idiopathic - Chronic ... Systemic Lupus Erythematosus ... #Causes #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Infectious • ... • Lymphoma • Leukemia ... Systemic Lupus Erythematosus ... Serum Sickness Hemolytic ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Rebound effect from treatment ... : Chronic infections ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Complications: 1) Infection ... neutropenia) ... #oncology #hematology ... #hemeonc #diagnosis
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... Diagnosis Neonate ... hypertension and/or drug treatment ... - Autoimmune neutropenia ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
: Autoimmune, Microangiopathic ... hemolytic anemia ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
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