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anemia causes algorithm hemolysis oncology thrombocytosis disease extravascular intravascular management agglutinin atlas autoimmune bloodcell calcium calculation comparison cppd deposition erythematosus
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Spherocytes • Treatment ... • Treatment: Warm ... Plasmapheresis - VA Joint ... #Anemia #hematology ... #diagnosis #comparison
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... Extravascular #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Warm AIHA • Cold ... circulation - Infections ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Rebound effect from treatment ... : Chronic infections ... #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... • AIHA: warm, cold ... drug induced • Infections ... #classification ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Diagnosis Algorithm ... • Bleeding • Hemolysis ... Infection) High ... #Anemia #MCV #Classification ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Diagnosis Algorithm ... Myelofibrosis Infectious ... effect following treatment ... #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology ... #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... Diagnosis Secondary ... Thrombocytosis): • Acute infection ... iron deficiency, hemolysis ... #hematology #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... Agglutination - Cold ... inclusions - If infection ... #workup #hematology
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