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causes algorithm anemia oncology purpura agglutinin bruising cold dermatology disease embolism enlarged extravascular framework hemolysis intravascular management mds monoclonal myelodysplasia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Rebound effect from treatment ... , Vasculitides, ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential ... Myelofibrosis Infectious ... effect following treatment ... following EtOH induced thrombocytopenia ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... ): • Acute infection ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... #hematology #secondary
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... uremic syndrome ... Extravascular #Causes #differential ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... DIC/TTP/HUS - Hemolytic ... #Diagnosis #hematology ... #rheumatology #
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Non-lmmune: • HELLP Syndrome ... HUS • DIC • Vasculitis ... • Infection ... #Causes #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Infectious • ... Bacterial • Viral ... vera, essential thrombocytosis ... Serum Sickness Hemolytic ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Schistocytes, thrombocytopenia ... cardiac valve, vasculitis ... inclusions - If infection ... #workup #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
- Differential ... Diagnosis Framework ... infiltration: malignancy, infection ... antiphospholipid syndrome ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... • Nephrotic Syndrome ... Heparin-induced thrombocytopenia ... 19 - PNH - Vasculitis ... pathophysiology #hematology
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