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hematology hemolysis algorithm causes hemolytic medications deficiency extravascular intravascular management treatment atlas bloodcell calculation cardiology chf classification clinical criticalcare druginduced
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... Diagnosis Framework ... Spherocytosis, G6PD ... Orotic aciduria, Drugs ... #Diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Enzyme Defects: G6PD ... Defects: Sickle cell anemia ... #Diagnosis #hematology
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
in Hemolytic Anemia ... medications #Hemolytic #Anemia ... #differential # ... diagnosis #pharmacology ... #table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
infection) - Drugs ... (Beta lactam antibiotics ... G6PD deficiency) ... Extravascular #Causes #differential ... #diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... G6PD, pyruvate kinase ... AIHA: warm, cold, drug ... #Differential #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... Defects • G6PD ... immune-complex hemolytic anemia ... #Diagnosis #Algorithm ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Bite Cell RBC: G6PD ... disorders, Oxidative drugs ... RBC #Morphology #differential ... #diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
suppression (e.g. drugs ... , G6PD deficiency ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Therapeutic Drug Level Monitoring Carbamazepine - Sample immediately before next dose (trough) Clozapine - Sample immediately
Therapeutic Drug ... -24 hours post dose ... - Intermittent dosing ... Ranges #Toxicology #Pharmacology ... #Diagnosis #Table
Drug-induced Hemolysis in G6PD Deficiency Medicines and other substances likely to be UNSAFE in moderate to severe
Drug-induced Hemolysis ... in G6PD Deficiency ... DrugInduced #Hemolysis #Pharmacology ... #Differential # ... Diagnosis #Table
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