25 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - Differential ... Diagnosis Table ... #Diagnosis #Table ... #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential ... : • Autoimmune ... (AIHAs) • Alloimmune ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Anemia - Hemolysis Diagnostic Algorithm
Autoimmune hemolytic anemia
Microangiopathic hemolytic anemia
Probable thalassemia

Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Diagnostic Algorithm Autoimmune ... hemolytic anemia ... Anemia #Algorithm #hematology ... #diagnosis #differential
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Warm vs Cold Autoimmune ... Autoimmune Hemolytic ... BostonChiefs #Warm #Cold ... #Autoimmune #Hemolytic ... #Anemia #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... Pathophysiology - Warm vs Cold ... Smear: spherocytes Cold ... #Hemolytic #Anemia ... Pathophysiology #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
idiopathic) - Autoimmune ... (AIHA)"Cold" (usually ... (e.g. primary cold ... Extravascular #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... Warm AIHA • Cold ... AIHA • Alloimmune ... Extravascular #Differential ... Algorithm #Causes #Hematology
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
DAT Results in Autoimmune ... , C3d ( +/- ) Cold ... ) Paroxysmal cold ... antiglobulin #test #DAT #Autoimmune ... #Hemolysis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... disease (diverse genotypes ... Agglutination - Cold ... elliptocytosis, autoimmune ... Algorithm #workup #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... > 10, no more hemolysis ... azathioprine Cold ... BrighamMedRes #AIHA #Autoimmune ... Treatment #management #hematology