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diagnosis differential causes algorithm hypokalemia management low metabolic medications table gitelman syndrome treatment chloride classification high pathophysiology renal summary urine
Diuretics sites of action on the nephron 1) Acetazolamide (carbonic anhydrase inhibitor) 2) Osmotic diuretics (e.g. mannitol) 3) Loop
Diuretics sites ... Metolazone) 5) Potassium-sparing ... diuretics (e.g. ... #pharmacology # ... nephrology #medications
Summary of Diuretic Agents Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction CARBONIC ANHYDRASE
Summary of Diuretic ... empagliflozin LOOP DIURETICS ... DIURETICS • Spironolactone ... Tolvaptan #Diuretics ... summary #table #nephrology
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... thiazide-like diuretics ... Postobstructive diuresis ... , Osmotic diuresis ... mimics thiazide diuretic
Diuresis in Critical Care - Achieving a Negative Fluid Balance Advantages Of A Negative Fluid Balance: •
Diuresis in Critical ... , address diuretic ... ) to normalize Potassium ... contraction metabolic alkalosis ... Early nephrologv
Diuretics - Pharmacology Thiazides diuretics: • Inhibit Na+ Cl- cotransporter in distal tubule • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Piretanide Potassium ... sparing diuretics ... nephrology #conversion
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Diuretics and Agents ... • Metabolic alkalosis ... Symport (Loop Diuretics ... Hyponatremia • Hypercalcemia ... #Nephrology #Pharmacology
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift: • Alkalosis ... • Discontinued diuretic ... Diagnosis #Algorithm #nephrology ... #low #potassium
Causes of Hyponatremia - Differential Diagnosis Algorithm Hypovolemia, UNa > 20: • Renal losses, Diuretic excess,
Renal losses, Diuretic ... and metabolic alkalosis ... Ketonuria, Osmotic diuresis ... renal failure Hypervolemia ... Algorithm #Causes #nephrology
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypokalemia Differential ... >20 mEq/24 h - Diuretics ... Gitelman's syndrome #Hypokalemia ... Diagnosis #Algorithm #nephrology ... #causes #low #potassium
Hyperkalemia Treatment Options Stabilize cardiac membrane: • IV Calcium (peaks 5-10 minutes) Decrease potassium concentration: • IV Fluids Shift
Hyperkalemia Treatment ... Fluids Shift potassium ... function) - Loop diuretic ... LouLectures #Hyperkalemia ... #nephrology
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