15 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... #differential #diagnosis ... #pathophysiology ... #pharmacology #
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
syndrome - Na-K-2Cl ... barrtin (recruits Cl ... or aquaporin-2 deficiency ... Kidney #Nephrology #Diagnosis ... #Differential #Table
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Iron Deficiency ... Heart Failure Pathophysiology ... and iron release Diagnosis ... composite endpoint of all-cause ... #heartfailure #diagnosis
Iron Deficiency in Congestive Heart Failure (CHF)

Iron deficiency (ID) in heart failure is a common comorbidity
Iron Deficiency ... (CHF) Iron deficiency ... Exercise capacity Diagnosis ... #Failure #CHF #pharmacology ... #pathophysiology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Differential Diagnosis ... - Protein S deficiency ... considered in all ... Venous #Arterial #pathophysiology ... #differential #diagnosis
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
filtered Na+/K+/Cl ... filtered Na+ and Cl ... Segments #Function #Pathophysiology ... #Tubules #Table ... #Pharmacology
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
myeloma, CML, AML ... Primary carnitine deficiency ... #Ammonia #Pathophysiology ... #Differential #Diagnosis
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
- Differential Diagnosis ... and Pathophysiology ... • Severe iron deficiency ... • Mitchell et al ... #Pathophysiology
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
Chlorpromazine ACh ... Block action of ACh ... arterioles -> less able ... #SideEffects #pharmacology ... #diagnosis #psychiatry
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
40% of patients diagnosed ... Inability to produce all ... antibodies) -> Complete deficiency ... Agammaglobulinemia #XLinked #pathophysiology