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diagnosis management differential lysis neurology tumor barre causes guillain hematology rhabdomyolysis tumorlysis acute apml cancer classification differentiation emergencies encephalopathy gbs
Tumor lysis syndrome (TLS) - Pathophysiology: → Massive tumor cell lysis → Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... , AML, NHL → AKI ... #TumorLysis #syndrome ... #TLS #Pathophysiology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
of Tumor Lysis Syndrome ... (TLS) and Treatment ... : • AKI (defined ... #TumorLysis #Syndrome ... #management #oncology
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... tetany ↑UA = AKI ... #TLS #Pathophysiology ... #oncology
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Kidney Injury (AKI ... malignancies Treatment ... Kidney #Injury #AKI ... #Cancer #Oncology ... Classification #Nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... , AKI, acute limb ... : • Pathophysiology ... #TLS #diagnosis
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... spontaneously (before any treatments ... malignancies Treatments ... #Tumor #Lysis #Syndrome ... #TLS #oncology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... HIV, Influenza, TSS ... Dermatomyositis) AKI ... - Pathophysiology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... HIV, Influenza, TSS ... declines > ALT) • AKI ... + myoglobin AKI ... #nephrology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... antibiotics TLS ... low Ca - q8 h TLS ... : - Seen with AML ... (~20 %) and APL
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Triggers: ATRA treatment ... Pathophysiology ... management #hematology #oncology
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